Sustiva (generic name efavirenz) is an antiretroviral pill used to help control HIV. It’s usually prescribed as part of a combination regimen to keep the virus suppressed and protect the immune system. If you or someone you care for takes Sustiva, this page gives short, useful facts you can use right away.
Take it at night. Efavirenz often causes dizziness and vivid dreams. Taking the dose just before bed usually makes those effects easier to handle.
Try to take it on an empty stomach. High‑fat meals raise drug levels and can increase side effects. Follow your prescriber's instructions about food.
Tell every provider about it. Efavirenz interacts with many drugs and supplements. Mention it to doctors, dentists, and any pharmacist so they can check for dangerous combos.
Avoid St. John's wort. That herbal remedy can make efavirenz much less effective. Also be cautious with anticonvulsants (carbamazepine, phenytoin), rifampin (used for TB), methadone, and some hormonal contraceptives—these all can change how efavirenz or the other drug works.
Sleep and mood changes are the most common: vivid dreams, trouble sleeping, dizziness, and mood swings. Don’t drive or operate heavy machinery until you know how the medication affects you.
Mental health symptoms can be serious for some people. If you feel depressed, have worsening anxiety, or notice thoughts of harming yourself, call your provider or local emergency services right away.
Skin rash and liver issues can happen. A mild rash is common, but if you get a spreading rash, blisters, or signs of liver trouble (yellow skin/eyes, dark urine, severe stomach pain), contact your clinician immediately.
Blood tests matter. Your doctor will check viral load and liver enzymes regularly. These tests show whether the drug is working and whether your liver is tolerating it.
Missed doses can matter more than you think. Consistent dosing helps prevent resistance. If you miss a dose, follow your clinic’s guidance—don’t double up without asking.
Pregnancy and planning. Efavirenz has been linked to risks if taken very early in pregnancy. If you’re pregnant or planning pregnancy, talk with your provider about choices and timing. Don’t stop or switch drugs without medical advice.
Finally, keep a simple list of everything you take—prescriptions, over‑the‑counter meds, and supplements—and share it at each visit. That one habit prevents a lot of problems and keeps your treatment on track.
Want deeper reads? Check the linked articles below for topics like drug interactions, how to manage side effects, and safe pharmacy tips.
Sustiva (efavirenz) is a common HIV medication. Learn about uses, side effects, dosage information, tips for taking, and important facts in this detailed article.
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