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When Doctors Say 'Do Not Substitute': Why Brand Drugs Are Sometimes Required

When Doctors Say 'Do Not Substitute': Why Brand Drugs Are Sometimes Required

Doctors write 'Do Not Substitute' on prescriptions when brand-name drugs are medically necessary-especially for narrow therapeutic index drugs like levothyroxine or warfarin. Here’s why generics aren’t always safe, how often this happens, and what patients should know.

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Dec 1, 2025 dave smith 3

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